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REVIEW ARTICLE: BIOMARKER SERIES
Year : 2021  |  Volume : 4  |  Issue : 3  |  Page : 516-523

Biomarker series: KRAS- A narrative review


1 Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India
2 Department of Section of Molecular Diagnostics, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India

Correspondence Address:
Ullas Batra
Sector 5, Rohini, Sir Chhotu Ram Marg, New Delhi - 110 085
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/crst.crst_189_21

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Non-small cell lung cancer (NSCLC) has emerged as the poster child of molecular medicine. Kirsten rat sarcoma (KRAS)-mutated NSCLC is a common yet heterogeneous entity with distinct clinical and prognostic characteristics. Therapeutically, targeting the KRAS mutation in NSCLC has been the most difficult challenge faced by scientists and drug developers and after decades of efforts, a final breakthrough in the form of KRAS G12C inhibitors has emerged. In this edition of the biomarker series, we review KRAS, its biology, clinical features, and the therapeutic options in KRAS-mutant NSCLC. We performed a thorough search in PubMed, Embase, and Scopus and finally included 59 articles to write this review.


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