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Year : 2021  |  Volume : 4  |  Issue : 4  |  Page : 668-676

Management of triple-negative breast cancer in the era of novel therapies: A narrative review

Department of Medical Oncology, Dr. B.R.A. IRCH, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Ajay Gogia
357, Gautam Nagar, New Delhi - 110 049
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/crst.crst_226_21

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The evolution of therapeutics for triple-negative-breast cancer (TNBC) has been lagging behind in comparison to that of other breast cancer subtypes. This review focuses on the recent developments with the potential to change future clinical practice. We searched the PubMed database for randomized trials on TNBC published in the past 2 years using the key term, “Triple-negative breast cancer.” Abstracts and outcomes of various studies presented at major oncology meetings were also assessed. A total of 54 studies were included in this review. Recent advances in molecular studies have delineated several cellular alterations revealing various targetable biomarkers. In addition, immunotherapeutic agents are being explored in the neoadjuvant setting and have shown major improvements in pathological complete response. Poly-adenosine diphosphate ribose polymerase inhibitors (PARPi) have transformed the management of TNBC, especially breast cancer gene-1/2 (BRCA1/2)-mutant and homologous recombination repair-deficient tumors. PARPi are now being utilized in the neoadjuvant setting, for maintenance following definitive treatment, and in metastatic disease. Sacituzumab govitecan has demonstrated improved outcomes in relapsed/refractory metastatic TNBC and has been approved for this indication. Capivasertib and ipatasertib have demonstrated promising results in patients harboring alterations in the phosphatidylinositol-3-kinase (PI3K)/protein kinase B pathway.

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