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Year : 2021  |  Volume : 4  |  Issue : 4  |  Page : 702-708

RET in non-small cell lung carcinoma: A narrative review

1 Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India
2 Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India

Correspondence Address:
Ullas Batra
Sector 5 Rohini, Sir Chhotu Ram Marg, New Delhi - 110 085
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/crst.crst_254_21

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The advent of stratified medicine and tailored therapies has caused non-small cell lung cancer (NSCLC) to become a subject of keen interest, with an emphasis on comprehensive genomic testing for driver mutations and biomarkers. The rearranged during transfection (RET) gene rearrangement has been observed in 1%–2% of all NSCLCs. In this edition of the biomarker series, we have reviewed the available literature on RET and its biology, along with the clinical features and therapeutic options for RET-rearranged NSCLC. For the purpose of this review, we performed a detailed search of the PubMed, Scopus, and My Cancer Genome databases using the keywords “RET,” “NSCLC,” “pralsetinib,” and “selpercatinib.” We included 42 articles in the final review. Studies suggest that RET rearrangement has emerged as a new biomarker of interest in NSCLC owing to the development and approval of selective RET inhibitors. Newer trials comparing RET inhibitors with chemotherapy and immune checkpoint inhibitors are underway. However, more studies are required to lucidly explain the underlying biology, including newer mechanisms of resistance to selective RET inhibitors, to guide drug development in future.

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