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Year : 2022  |  Volume : 5  |  Issue : 1  |  Page : 105-110

Romiplostim – A narrative drug review

Department of Medical Oncology, Mahamana Pandit Madan Mohan Malviya Cancer Centre and Homi Bhabha Cancer Hospital, Tata Memorial Centre, Varanasi, Uttar Pradesh, India

Correspondence Address:
Anuj Gupta
Department of Medical Oncology, Mahamana Pandit Madan Mohan Malviya Cancer Center and Homi Bhabha Cancer Hospital (A Unit of Tata Memorial Center, Mumbai), Varanasi, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/crst.crst_17_22

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Chemotherapy-induced thrombocytopenia (CIT) is a challenging condition that is routinely encountered in oncology practice. Currently, the sole therapeutic modality for CIT is the transfusion of platelets, especially when the platelet count is less than 20,000 per microliter. Chemotherapy dose reductions and dose delays result, which may lead to compromised outcomes. Drugs like oprelvekin and avatrombopag have been tried for CIT, but are not in routine use due to severe adverse effects. Romiplostim and eltrombopag are thrombopoietin receptor agonists that have been successfully used in benign conditions like idiopathic thrombocytopenic purpura (ITP), but are not approved for use in CIT. We searched PubMed for studies published in the last 5 years (2017–2021), using the key words “romiplostim,” “cancer,” and “malignancy”. We excluded articles that were related to benign causes of thrombocytopenia, articles for which the full text was not available, non-human studies, and articles in a language other than English. A total of 34 articles were included. In this narrative drug review, we have focused on romiplostim and the evidence supporting its use in both solid and hematologic malignancies.

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