|LETTER TO EDITOR
|Year : 2022 | Volume
| Issue : 1 | Page : 195-196
Trastuzumab deruxtecan in HER2-mutant non-small-cell lung cancer
Shuvadeep Ganguly, Ajay Gogia
Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India
|Date of Submission||16-Feb-2022|
|Date of Decision||26-Feb-2022|
|Date of Acceptance||01-Mar-2022|
|Date of Web Publication||31-Mar-2022|
Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi - 110 029
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Ganguly S, Gogia A. Trastuzumab deruxtecan in HER2-mutant non-small-cell lung cancer. Cancer Res Stat Treat 2022;5:195-6
Li et al. recently reported the impressive response rate of trastuzumab deruxtecan in refractory metastatic HER2-mutant non-small-cell lung cancer (NSCLC). It is, however, pertinent to note that patients with HER2-mutant NSCLC have higher chance of developing brain metastases during the course of treatment, which has been reported in up to 47% cases. Hence, systematic intracranial response assessment is imperative to make any real conclusions about the intracranial penetration and efficacy of the above antibody–drug conjugate.
The study also reports the occurrence of drug-related interstitial pneumonitis in 26% patients (24/91; dose of 6.4 mg/kg), which is higher compared to that observed with the same agent in breast cancer (13.6% at 5.4 mg/kg) or gastric cancer (6.4% at 6.4 mg/kg). Use of a lower dose in breast cancer may partly explain the difference. However, it is more likely that patients with refractory NSCLC have received prior immunotherapy (60/91, 66%) and/or have a prior smoking history (39/91, 43%), which may predispose them to a higher incidence of drug-related interstitial pneumonitis. Exploring biomarkers that may predict the development of pneumonitis and cautious patient selection are crucial to mitigate this clinically significant adverse event.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
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. Trastuzumab deruxtecan in HER2
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Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, et al
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